Lipidomics Applications for Disease Research

Lipidomics is an important branch of metabolomics, which aims at the detailed analysis of lipid species and their multiple roles in the living system. In recent years, the development of various analytical methods for effective identification and characterization of lipids has greatly promoted the process of lipidomics. Meanwhile, as many diseases demonstrate a remarkable alteration in lipid profiles compared with that of healthy people, lipidomics has been extensively introduced to disease research. The comprehensive lipid profiling provides a chance to discover novel biomarkers for specific disease. In addition, it plays a crucial role in the study of lipid metabolism, which could illuminate the pathogenesis of diseases.

Due to the diversity of lipids, the development of analytical methods for lipidomics is challengeable. MS, and especially its coupling with chromatographic separations, is the most widely used technique in lipidomics. The MS analysis of lipids in biological samples has provided abundant information for clinical interpretations of many diseases. With extensive experience and state-of-the-art technologies, Creative Proteomics provides comprehensive lipidomics services from lipid extraction, lipid detection and data analysis for disease research.

Cancer

Lipidomics has been applied to the biomarker discovery of cancer for many years, and it can provide assistance in revealing the pathogenesis related to cancer. Creative Proteomics provides comprehensive lipidomics services from lipid extraction, lipid detection and data analysis for cancer research.

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Atherosclerosis

As lipids are abundant constituents of the vascular plaque and lipoproteins, this disease is believed to stem from the imbalance of the lipid metabolites in the affected organism. Creative Proteomics provides comprehensive lipidomics services to help our customer generating new insight into atherosclerosis pathophysiology and accelerating the process of drug development.

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Cardiovascular Diseases

Creative Proteomics provides customized lipidomics solutions to help expand the vision of cardiovascular disease pathogenesis and facilitate advances in cardiovascular disease drug development research.

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Diabetes Mellitus

Lipids play a significant role in both the causes and consequence of diabetes mellitus (DM). Recently, lipidomics has become a powerful approach to unravel the complex relationships between metabolism and progression to DM.

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Alzheimer's Disease

As lipids can be linked to the hallmarks of AD, an in-depth analysis of lipid composition changes in AD might provide a different perspective on AD neuropathology and potentially different AD biomarkers. Creative Proteomics offers cutting-edge mass spectrometry (MS)-based lipidomics services for Alzheimer's disease research.

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Kidney Disease

Lipids play important roles in the regulation of normal kidney function and pathogenesis of kidney disease. Thus, analysis of key lipid mediators has emerged as an important tool in the diagnosis, prognosis, and treatment of kidney disease.

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Skin Diseases

Several reported studies demonstrate that alteration of lipid composition may play an important role in an impaired skin barrier, which is a major cause of several inflammatory skin diseases. With decades of operational experience and technology platform, Creative Proteomics provides reliable, rapid, and cost-effective plant lipidomics services based on LC-MS methods for skin diseases research.

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Immune Disease

Creative Proteomics provides customized lipidomics solutions to analyze lipid profiles in different samples, screen for differentially expressed lipids, identify and quantify target lipids, and facilitate research on potential mechanisms of immune diseases, early diagnosis and drug efficacy.

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