Lipidomics in Environmental Toxicology Research
The versatility of lipidomic applications has been increasingly recognized in environmental toxicology in recent years. The unmatched diversity and ubiquitous nature of lipids makes them exceptional candidates in the discovery of sensitive biomarkers for various diseases in animals and humans. Lipidomics as a tool to examine the effects of environmental stress (e.g., exposure) using in vitro and in vivo models. Specifically, this includes lipidomic examinations of exposure to organic pollutants, such as per- and polyfluoroalkyl substances and bisphenols, and heavy metals, such as arsenic and mercury, and radiation, among others, in cell culture, animal and human studies. In conclusion, the adoption of novel lipidomics strategies has tremendous potential in environmental toxicology. With decades of operational experience and technology platform, Creative Proteomics provides reliable, rapid, and cost-effective untargeted lipidomics and targeted lipidomics services based on GC/LC-MS and shot-gun methods for environmental toxicology research.
Organic Pollutants
These lipophilic compounds are known to bioaccumulate in blood-rich tissues and have been shown to modulate lipid levels in various models through diverse mechanisms, including nuclear receptor activation. Creative Proteomics provides reliable, rapid, and cost-effective untargeted lipidomics and targeted lipidomics services based on GC/LC-MS and shot-gun methods for environmental toxicology research (Organic Pollutants).
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Heavy Metals
Heavy metals, such as arsenic and mercury, are of high environmental concern owing to their persistent and bioaccumulative nature. These contaminants are already in their elemental forms and, therefore, cannot be broken down by conventional means such as chemical, microbial, or photolytic degradation. Recent studies have used lipidomics to highlight the effects of heavy metals on various systems and tissues. Creative Proteomics provides reliable, rapid, and cost-effective untargeted lipidomics and targeted lipidomics services based on GC/LC-MS and shot-gun methods for environmental toxicology research (Heavy Metals).
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Radiation
Risks of radiation exposure range from nuclear energy accidents to potential terrorism and workplace industrial hazards. Biodosimetry methods are required to aid in the recovery from a potential mass exposure to radiation by determining absorbed dose, assigning triage, and determining useful countermeasures. With decades of operational experience and technology platform, Creative Proteomics provides reliable, rapid, and cost-effective untargeted lipidomics and targeted lipidomics services based on GC/LC-MS and shot-gun methods for environmental toxicology research (radiation).
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