Sphingolipids are lipids composed of a molecule of long-chain fatty acids, a molecule of sphingosine or its derivatives, and a molecule of polar head alcohol. The sphingolipids can be divided into three subgroups: sphingolipids, sphingolipids and gangliosides. Spingolipids (SP) are the most diverse lipids due to the variety of their structural components.

Sphingolipids are found in all animals, plants, and fungi, as well as in some prokaryotes and viruses. Sphingolipids are not only components of cell membranes, but also involved in signaling pathways that regulate cell growth, differentiation, proliferation, and death.

Sphingolipids play an important role in the evolution of tumors and the development of multi-drug resistance in tumor cells, vascular endothelial cell signaling and atherosclerosis formation, the regulation of biological development and lifespan, as well as virus and bacterial infection.

Creative Proteomics is based on a highly stable, repeatable, and highly sensitive separation, characterization, identification and quantitative analysis system, providing rapid, cost-effective spingolipid analysis to help you accelerate the process of research.

Our Sphingolipids Analysis Service

Creative Proteomic is based on liquid chromatography-triple quadrupole mass spectrometry technology, using target compound standards for method optimization, method validation, biological sample collection, metabolite extraction, mass spectrometry detection, data analysis, etc. to provide you with sphingolipids detection services.

Fig1. The workflow of sphingolipids analysis service (Creative Proteomics)

Featured Sphingolipids Analysis Service

Sample Requirements

We routinely cover a rich variety of sample types, including cells, conditioned medium, tissue, blood, plasma, plants, fungi, prokaryotic organisms and viruses for our customer.

Extraction of lipids should be performed right after sample collection steps, otherwise, samples should be stored at -80°C, and shipped with dry ice. After sample collection, you can either perform sample pretreatment, or contact us for specific sample pretreatment service.

Why Choose Us?

• One-stop analysis service: Provide comprehensive services from sample preparation, standard addition, mass spectrometry analysis, data processing, and data comparison.
• Fast turnaround time: 1-4 weeks.
• Provide a detailed report at the end of the entire project, including the experimental process, MS/MS instrument parameters, quality control parameters, raw data and the final result of the comparison.

If you have any questions about our sphingolipids analysis service, please contact us.

Reference:

1. Sipione S.; et al. Gangliosides in the brain: physiology, pathophysiology and therapeutic applications. Frontiers in neuroscience. 2020, 14.

Services:

• Glycerophospholipids Analysis Service
• Glycerolipids Analysis Service
• Fatty Acyls Analysis Service
• Sterol Lipids Analysis Service
• Phospholipids Analysis Service
• Prenol Lipids Analysis Service
• Saccharolipids Analysis Service
• Polyketides Analysis Service
• Untargeted Lipidomics
• Targeted Lipidomics
• Lipidomics Bioinformation Analysis
• Metabolic Flux Analysis Services
• MALDI-Imaging Lipidomics Services
• Lipidomics Service

Resource:

Platform:

• Mass Spectrometry Systems
• Chromatographic Systems
• Shot-Gun Lipidomics
• GC/LC-MS Lipidomics
• Sample Guidelines