Thromboxane, a type of eicosanoid produced by platelets, is a signaling molecule derived from fatty acids and is produced primarily by platelets in response to injury. Thromboxanes promote platelet aggregation, vasoconstriction and clot formation, all of which are important factors in the hemostatic process. In addition, they can cause vasoconstriction and bronchoconstriction, and are involved in inflammation and wound healing.
However, excessive thromboxane production can also lead to pathological conditions such as thrombosis, for example, the formation of blood clots in blood vessels and may lead to serious health problems. Examples include heart attacks, strokes, etc.
Schematic representation of the mechanism of action of thromboxane in patients with atherosclerosis (Szczuko M et al., 2021).
Thromboxane A2 (TXA2) and thromboxane B2 (TXB2) are important bioactive compounds produced by platelets, endothelial cells and other cells in the body. They are part of the arachidonic acid cascade of the body's inflammatory response. Understanding the role and effects of thromboxane A2 (TXA2) and thromboxane B2 (TXB2) is important for the management of various diseases and conditions, such as many diseases including cardiovascular disease.
Thromboxanes, a class of arachidonic hormones. It acts as a vasoconstrictor and a powerful hypertensive agent and promotes platelet agglutination and smooth muscle contraction. Thromboxane, first isolated from platelets, causes arterial constriction, induces platelet aggregation, and promotes thrombosis. Thromboxane can be obtained from prostaglandin H2 by the action of thromboxane A synthase in platelets. Changes in thromboxane levels are seen in atherosclerosis, angina pectoris, coronary artery disease, diabetes, hyperlipidemia, etc. Elevated TXA2/PGI2 ratio easily leads to platelet aggregation and thrombus formation, prompting atherosclerosis and coronary artery disease.
Thromboxane analysis can be used to understand thromboxane levels, which in turn can be used to help analyze platelet function and the effects of potential cardiovascular disease on the organism. Some of the common analytical methods used to measure thromboxane levels in biological samples include.