Empowering High-Precision Lipid Analysis with Advanced Mass Spectrometry and Rigorous QC
At Creative Proteomics, our lipidomics platform delivers accurate, publication-ready data to help you confidently profile lipid species, validate biomarkers, or explore structural diversity. Powered by high-end mass spectrometry and rigorous quality control, we help researchers overcome challenges in sensitivity, reproducibility, and data interpretation.
Key Advantages:
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Robust lipid profiling powered by optimized chromatographic separations, multi-mode ionization, and accurate mass detection.
For absolute quantification of predefined lipid species using triple quadrupole LC-MS/MS.
For global profiling of lipidomes with high-resolution mass spectrometry (e.g., Orbitrap, QTOF).
Structural Lipidomics
For in-depth analysis of lipid isomers and subclass differentiation via MS/MS and ion mobility.
| RP-UHPLC | HILIC | Normal Phase LC |
|---|---|---|
| For non-polar lipids: TAG, DAG, CE, FA | For polar lipids: PC, PE, PI, PS, SM | For class-based profiling or niche assays |
| C18-based, high-resolution LC | Amide/HILIC columns for class separation | Legacy or custom lipidomics workflows |
| Common in both targeted and untargeted | Enhances subclass coverage | Limited use, for special lipidomics |
Each method is matched to sample type and project goal to maximize class coverage and detection resolution.
| Method | Description | Use Case | Performance |
|---|---|---|---|
| Relative Quantification | Peak area normalization across samples | Comparative studies, discovery | CV < 15% |
| Absolute Quantification | Stable isotope-labeled internal standards (e.g., SPLASH Lipidomix) | Biomarker validation, PK studies | R² > 0.99, wide dynamic range |
We employ standard curves and internal calibrants to ensure consistent quantitation across batches.
Parameter Highlights
Analytical Performance
Lipid Classes Supported
Use Cases
Parameter Highlights
Analytical Performance
Lipid Classes Supported
Use Cases
Parameter Highlights
Analytical Performance
Lipid Classes Supported
Use Cases
Parameter Highlights
Analytical Performance
Lipid Classes Supported
Use Cases
Parameter Highlights
Analytical Performance
Lipid Classes Supported
Use Cases
Parameter Highlights
Analytical Performance
Lipid Classes Supported
Use Cases
Parameter Highlights
Analytical Performance
Lipid Classes Supported
Use Cases
Tell us your goals & sample
We provide a tallored quotation
Send your samples with proper handling
We provide lipid profiling & QC
Receive annotated data & bioinformatics
Explore how our advanced lipid analysis platform can support your research goals
We understand that downstream usability is just as important as data generation. Our lipidomics platform provides clean, publication-ready datasets tailored for biomarker discovery, mechanistic studies, or regulatory submission.
Typical Data Deliverables Include:
High-confidence lipidomics begins with a rigorous quality control framework. Every project is processed with internal standards, spike-in controls, and method validation to ensure repeatability and accuracy.
Our QC Strategy Covers:
| Control Element | Description |
|---|---|
| Internal Standards | Class-specific isotope-labeled mix (e.g., SPLASH) added to every sample |
| Pooled QC Samples | Inserted every 10 runs to monitor precision and drift |
| Reproducibility Thresholds | RSD <15% across biological and technical replicates |
| System Suitability | Verified daily by standard response and retention metrics |
| Linearity & Calibration | 4–6 point standard curve validation, R² > 0.99 |
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