With extensive experience and state-of-the-art technologies, Creative Proteomics use highly sensitive LC-MS/MS method for the rapid identification and quantification of cytidine diphosphate diacylglycerol in different sample types, which can satisfy the needs of academic and industrial study.
Cytidine diphosphate diacylglycerol (CDP-DAG) is a key intermediate in the synthesis of phosphatidylinositol (PI) and cardiolipin (CL). Both PI and CL have highly specialized roles in cells. PI can be phosphorylated and these phosphorylated derivatives play major roles in signal transduction, membrane traffic, and maintenance of the actin cytoskeletal network. CL is the signature lipid of mitochondria and has a plethora of functions including maintenance of cristae morphology, mitochondrial fission, and fusion and for electron transport chain super complex formation. Further, CDP-DAG is linked to lipid droplet size in adipocytes. In human tumor tissues, increased CDP-DAG enhanced tumor proliferation.
The combination of MS instrument and liquid chromatography (LC) can effectively separate target lipid molecules from complex samples. High-quality and accurate lipid level analysis helps to study the changes in the content of CDP-DAG under physiological and other pathological conditions, and accelerate the analysis of biomarkers and related disease mechanisms.
|CDP-DAG||CDP-DAG 34:1;0||CDP-DAG 36:2;0|
Fig 2. The workflow of cytidine diphosphate diacylglycerol analysis service
Structural details: species level
Precision: pmol & mol%
Variants identified: <10
Delivery time: 2-4 weeks
Blood/plasma: 500 ul/sample
Tissue: 200 mg/sample
With years of experience in lipidomics analysis services, Creative Proteomics has a good reputation in supporting the detection and quantification of a variety of lipids. Based on a highly stable, reproducible and highly sensitive separation, characterization, identification and quantitative analysis system, combined with LC-MS/MS, we provide reliable, fast and cost-effective CDP-DAG analysis services. If you have any questions about our CDP-DAG targeted lipidomics services, please contact us.