Phosphatidylethanolamine (PE) is the second most abundant phospholipid in mammalian cells. PE comprises about 15–25% of the total lipid in mammalian cells. It is enriched in the inner leaflet of membranes, and it is especially abundant in the inner mitochondrial membrane.
PE has quite remarkable activities, it is a lipid chaperone that assists in the folding of certain membrane proteins, it is required for the activity of several of the respiratory complexes, and it plays a key role in the initiation of autophagy.
Fig 1. PE in cancer and ferroptosis (Patel D, et al., 2017)
PE also play an important role in lipid-induced stress in the endoplasmic reticulum (ER), Parkinson's disease (PD), ferroptosis, and cancer.
Therefore, identification the level of PE can offer novel biomarkers for specific disease, also provide new insights for us to deeply understand the pathogenic mechanism of diseases.
Creative Proteomics provides you with efficient and accurate phosphatidylethanolamine qualitative and quantitative detection services through advanced chromatography and mass spectrometry platforms.
Absolute quantification: Use external standard method to quantify, and use internal standard for correction, qualitative and quantitative is more accurate.
High sensitivity: We use liquid chromatography coupled with triple quadrupole mass spectrometers for phosphatidylethanolamine analysis service (Triple Quad™ 6500 LC-MS/MS System).
Fig 2. The workflow of phosphatidylethanolamine analysis service.
We routinely cover a rich variety of sample types, including cells, cell medium, serum, tissue, et al. for our customer.
If you have any questions about our phosphatidylethanolamine detection service, please contact us.