Exosomes are composed of multiple components, including proteins, nucleic acids, lipids, and other metabolites. Exosomes are considered to be a novel and effective intercellular communication carrier. Adjacent cells or distant cells bind to recipient cells through exosomes and release biologically active molecules such as lipids, proteins and nucleic acids, which can exchange genetic or metabolic information. Lipids not only play an important role in the structure of exosomal membranes, but also play an important role in the formation and release of exosomes into the extracellular environment. Analyzing the lipid composition of exosomes is of great significance for understanding the biological characteristics of vesicles and studying their potential medical applications.

Fig. 1 Regulation of exosomes on lipid metabolism. (Wang W et al., 2020)

Exosomes lipidomics analysis can help us to understand vesicle biogenesis and function, identify lipid-based biomarkers and unravel its monitoring function in diseases. Creative Proteomics provides you with a one-stop service of separation and purification from exosomes, lipid molecule extraction, lipid qualitative and quantitative detection and data analysis.

Our Exosomes Lipidomics Services

Based on the HPLC-MS technology platform, we can:

• Discover new circulating biomarkers
• Analysis and identification of lipids and their metabolites
• Study lipid metabolism pathways and networks
• Analyze lipid function and metabolic regulation

Fig2. The workflow of exosomes untargeted lipidomics.

Sample Requirements

Why Choose Us?

• Fast turnaround time: 2-4 weeks.
• Professional platform: Cutting-edge apparatuses, reliable data and reproducible process.
• Bioinformatics service: Univariate analysis, multivariate analysis, difference analysis, function analysis, pathway analysis, etc.
• Detailed report: A detailed report to our clients, including experiment procedures and parameters of instruments, MS data with putative identification based on the m/z ratio of the analytes, and customized bioinformatics analysis.

If you have any questions about our exosomes lipidomics service, please contact us.

Reference:

1. Wang, W. et al. The crosstalk: exosomes and lipid metabolism. Cell Commun Signal. 2020, 18, 119.

Services:

• Mammalian Lipidomics Service
• Microbial Untargeted Lipidomics Service
• Plant Untargeted Lipidomics Service
• Algae Lipidomics Analysis Service
• Foods Lipidomics Service
• Untargeted Lipidomics
• Targeted Lipidomics
• Lipidomics Bioinformation Analysis
• Lipidomics Service

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