Creative Proteomics has developed a reliable and reproducible method using highly sensitive LC-MS/MS method for the rapid identification and quantification of LPE O- in different sample types, which can satisfy the needs of academic and industrial study in your lab.
Ether-linked lysophosphatidylethanolamine (LPE O-) is a glycerophosphoethanolamine, a type of glycerophospholipid. Their structure consists of a glycerol backbone connected to fatty alcohols through ether bonds and phosphoethanolamine molecules. Fatty acids can be variable length, hydroxylated, and contain double bonds. Little is known about the biological functions of ether-linked lysophosphatidylethanolamine, but they are precursors of ether-linked phosphatidylethanolamine. In the human retinal pigment layer that nourishes retinal visual cells, LPE O- is related to the formation of diretinoic acid. Bisretinoids are a type of fluorescent molecules that are formed in photoreceptor cells and cause certain retinal diseases. Therefore, it is suggested that LPE O- plays a role in retinal health.
The combination of MS instrument and liquid chromatography (LC) can effectively separate target lipid molecules from complex samples. High-quality and accurate lipid level analysis helps to study the changes in the content of LPE O- under physiological and other pathological conditions, and accelerate the analysis of biomarkers and related disease mechanisms.
|LPE O- 18:1;0||LPE O-||LPE O- 16:0;0|
Fig 2. The workflow of ether-linked lysophosphatidylethanolamine analysis service
Structural details: species level
Precision: pmol & mol%
Variants identified: >25
Delivery time: 2-6 weeks
Blood/plasma: 500 ul/sample
Tissue: 200 mg/sample
With years of experience in lipidomics analysis services, Creative Proteomics has a good reputation in supporting the detection and quantification of a variety of lipids. Based on a highly stable, reproducible and highly sensitive separation, characterization, identification and quantitative analysis system, combined with LC-MS/MS, we provide reliable, fast and cost-effective LPE O- analysis services. If you have any questions about our LPE O- targeted lipidomics services, please contact us.