Lipids are a class of biomolecules that are insoluble in water and readily soluble in non-polar organic solvents. They are involved in regulating a variety of life activities, including biofilm composition, cell development and differentiation, apoptosis, energy conversion, material transport, and information recognition and transmission. Lipidomics is a research method for comprehensive analysis and identification of all lipids in an organism, which can reveal the relationship between lipids and physiological or pathological changes in the organism by identifying key differential lipids and metabolic networks.
In atherosclerosis studies, lipids are not only passive participants in fatty streak lesions and atherosclerotic plaque accumulation, they also exhibit biological activity and alter the metabolism of several cell types critical for the development of atherosclerosis. Quantitative and compositional analysis of plasma lipids and lipoproteins in mice allows exploration and screening of lipids and lipoproteins associated with increased atherosclerosis.
Mouse is a common animal model used in basic research such as biopharmaceutical and drug development. Exploring lipid profiles in mouse models will accelerate scientific progress.
Creative Proteomics provides mouse lipidomics analysis services, our services include but are not limited to:
We have a complete technology platform for identification and quantification of mouse lipidomics, including GC-FID, GC-MS and LC-MS. Data analysis includes PCA, PLS-DA, PLS-R and univariate statistics. Generate a lipid list and classify the data based on the selected statistical test (f-test, t-test or regression and export list) for further analysis, such as enrichment and KEGG pathway analysis.
Fig1. The workflow of mouse lipidomics service.
We can accept many sample types, including cell, tissue, serum, plasma, urine, and other biological fluids.
Store at -80℃ after quick freezing in liquid nitrogen; send on dry ice.
If you have any questions about our mouse lipidomics services, please contact us.