Lipids are a class of biomolecules that are insoluble in water and readily soluble in non-polar organic solvents. They are involved in regulating a variety of life activities, including biofilm composition, cell development and differentiation, apoptosis, energy conversion, material transport, and information recognition and transmission. Lipidomics is a research method for comprehensive analysis and identification of all lipids in an organism, which can reveal the relationship between lipids and physiological or pathological changes in the organism by identifying key differential lipids and metabolic networks.
In atherosclerosis studies, lipids are not only passive participants in fatty streak lesions and atherosclerotic plaque accumulation, they also exhibit biological activity and alter the metabolism of several cell types critical for the development of atherosclerosis. Quantitative and compositional analysis of plasma lipids and lipoproteins in mice allows exploration and screening of lipids and lipoproteins associated with increased atherosclerosis.
Mouse is a common animal model used in basic research such as biopharmaceutical and drug development. Exploring lipid profiles in mouse models will accelerate scientific progress.
Creative Proteomics provides mouse lipidomics analysis services, our services include but are not limited to:
- Triglyceride determination
- Total plasma cholesterol assay
- High-density lipoprotein cholesterol assay
- Tissue lipid analysis
- Differential lipid screening
Our Mouse Lipidomics Service
We have a complete technology platform for identification and quantification of mouse lipidomics, including GC-FID, GC-MS and LC-MS. Data analysis includes PCA, PLS-DA, PLS-R and univariate statistics. Generate a lipid list and classify the data based on the selected statistical test (f-test, t-test or regression and export list) for further analysis, such as enrichment and KEGG pathway analysis.
Fig1. The workflow of mouse lipidomics service.
Sample Requirements
We can accept many sample types, including cell, tissue, serum, plasma, urine, and other biological fluids.
- Serum/plasma/urine/ other biological fluids ≥ 200 ul /sample
- Animal tissue/feces related samples ≥ 200 mg/sample
Store at -80℃ after quick freezing in liquid nitrogen; send on dry ice.
Why Choose Us?
- One-stop services from prepare the samples, run the mass spectrometric analysis, process the data, perform statistical analysis, and identify the compounds.
- Compatible with a variety of types of samples, ranging from all kinds of tissues and cell samples to body fluids, etc.
- Provides a comprehensive visual report of the results. The report will help to answer your study questions, and hopefully create a few new ones to follow.
- Visualize data results and provide actionable advice on how to leverage them in your research or business.
If you have any questions about our mouse lipidomics services, please contact us.
* Our services can only be used for research purposes and Not for clinical use.
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