Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are important omega-three polyunsaturated fatty acids (ω-3 PUFAs) that play a pivotal regulatory role in the resolution of inflammation.
Resolvins (Rvs), biosynthesized from essential ω-3 PUFAs EPA and DHA as precursors, are thought to have more potent anti-inflammatory and pro-resolving actions than EPA and DHA themselves. Studies have revealed that Rvs exert anti-inflammatory effects in animal models of acute kidney injury, acute lung injury, ulcerative colitis, and neurodegenerative diseases, providing a new approach for the treatment of inflammatory diseases.
Fig 1. Biosynthetic routes and classification of resolvins (Li et al., 2020)
Rvs are effective compounds that terminate the inflammatory response to maintain health. Rvs exert anti-inflammatory and proinflammatory subsidence effects by affecting signaling pathways, such as MAPK, NF-κB, PI3K, miRNAs, apoptosis, and PPAR-γ. Rvs show great anti-inflammatory effects in neurodegenerative diseases, neuroimmune diseases, and cerebrovascular disorders, thus providing a new way of thinking for the treatment and prevention of neurological diseases.
Creative Proteomics provides comprehensive resolvins targeted lipidomics services from lipid extraction, lipid detection and data analysis for biomedical research institutions, biotechnology and pharmaceutical companies.
Absolute quantification: Use external standard method to quantify, and use internal standard for correction, qualitative and quantitative is more accurate.
High sensitivity: We use liquid chromatography coupled with triple quadrupole mass spectrometers for resolvin analysis service (Triple Quad™ 6500 LC-MS/MS System).
Fig 2. The workflow of resolvins targeted lipidomics
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