Mitochondrial lipids participate in biological functions such as membrane structure and fluidity, signal transduction, and cellular energy storage.
Mitochondrial dysfunction has a high incidence in many cancers and other metabolic diseases. Therefore, it is urgent to investigate and clarify the changes in mitochondrial metabolism caused by diseases. Mitochondrial lipidomics analysis will directly find out the potential functional changes of lipid pathways and signaling networks at the subcellular level through its outstanding ability, and will play an important role in the research of mitochondrial diseases-related diseases.
The contribution of mitochondria to cell content is small, and the analysis of the whole cell may not be suitable for monitoring the changes of mitochondria. Therefore, lipidomics analysis specifically targeting mitochondria is necessary to understand the lipid pathways induced by the environment and diseases. Creative Proteomics provides one-stop mitochondrial untargeted lipidomics services from mitochondrial separation, lipid extraction, lipid detection and data analysis.
Based on HPLC-MS technology and rich sample analysis experience, we can process a variety of conventional biological specimens, including whole cells, tissues, plasma, serum and urine. One analysis can cover hundreds of metabolites or lipid types, which is enough to clarify the global metabolism and lipid network in depth.
Fig 1. The workflow of mitochondrial untargeted lipidomics.
If you have any questions about our mitochondrial lipidomics service, please contact us.