Lipidomics Applications for Pharma & Biotech

With more than 180,000 different molecular species, lipids form a vast and extraordinary class of biomolecules. Each of these lipids has a unique chemical structure and biophysical properties. Functioning as structural components of membranes, as medium for energy storage, as anchor for proteins, or as intra- and inter-cellular signaling molecules, lipids play diverse roles and are involved in numerous biological processes. Numerous human pathologies, including common conditions such as obesity, diabetes, cardiovascular disease, cancer, inflammatory disease and neurodegeneration, involve changes in lipid metabolism. Likewise, a growing number of drugs are being developed that directly or indirectly affect lipid metabolic pathways. Instead of classical and cumbrous radiochemical analyses, lipid profiling by mass spectrometry (MS)-based lipidomics holds great potential as companion diagnostic in several steps along the drug development process.

Fig1. Lipidomics in drug development (Dehairs, J.; et al, 2015)

Creative Proteomics provides reliable, rapid, and cost-effective lipidomics services for pharma & biotech research. We will use our expertise to help you interpret the results and provide you with actionable recommendations on how to utilize these results in your research or business.

Target Discovery

Since its development, MS-based lipidomics has been applied for the analysis of lipids in numerous disease conditions. Both LC-MS and shotgun lipidomics have been very successful in this context. Creative Proteomics provides a perfect lipidomics platform for drug target discovery.

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Identification of Candidate Drugs

Creative Proteomics identifies effective drugs based on the unique changes in lipid profiles each compound produces. Particularly, the capacity of lipid extraction can be substantially increased by the use of robotic liquid handling stations. Sample injection can also be automated by using robotic sample injection and ionization devices.

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Biomarker Analysis

Monitoring the alterations of lipid metabolites of certain molecular species in biological samples as influenced by external stimuli or disturbance by disease processes will be helpful for the discovery of lipid metabolites indicative of metabolic disorders or diseases. Creative Proteomics provides comprehensive lipidomics services for biomarker analysis.

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