Maresins Analysis Service

Maresins are a new class of anti-inflammatory and pro-lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. It has a conjugated double bond system and shows strong anti-inflammatory and solubilizing activities. Maresins limit the further recruitment of PMN, inhibit the infiltration of neutrophils in the body, and stimulate the non-inflammatory recruitment of monocytes.

When macrophages encounter maresins, they increase phagocytosis and efferocytosis, resulting in the removal of microbes. Biosynthesized maresins counterregulate the proinflammatory cytokines such as IL-1β, IL-6, and TNF-α. They also regulate nuclear factor kappa B (NF-κB) gene products and increase the regulation of T cell de novo synthesis and intracellular levels of cyclic adenosine monophosphate, regenerate tissue, and play a role in antinociceptive action.

Maresins in the resolution pathwayFig1. Maresins in the resolution pathway (Tang S.; et al, 2018)

Creative Proteomics provides comprehensive maresins analysis services from lipid extraction, lipid detection and data analysis for biomedical research institutions, biotechnology and pharmaceutical companies.

Our Maresins Analysis Service

Absolute quantification: Use external standard method to quantify, and use internal standard for correction, qualitative and quantitative is more accurate.

High sensitivity: We use liquid chromatography coupled with triple quadrupole mass spectrometers for maresins analysis service (Triple Quad™ 6500 LC-MS/MS System).

The workflow of maresins targeted lipidomics.Fig 2. The workflow of maresins targeted lipidomics.

Sample Requirements

SampleSample RequirmentsTimeLine
Cell lines5x106-1x107 cells2-4 weeks
Primary cells2x106 cells4-8 weeks

Why Choose Us?

  • Fast turnaround time: 1-4 weeks.
  • High throughput: Only one injection can run both quantitative MRM and qualitative QTRAP scans to maximize throughput.
  • One-stop analysis service: Provide comprehensive services from sample preparation, standard addition, mass spectrometry analysis, data processing, and data comparison.
  • Bioinformatics analysis: we provide data processing (e.g., data alignment, feature detection), feature prioritization (e.g., principal component analysis, heat maps, ANOVA/t-test, multivariate statistical analysis, self organizing maps, volcano plots, and network activity prediction), and lipid identification services.
  • Detailed report: Experimental process, MS/MS instrument parameters, quality control parameters, raw data and the final result of the comparison.

If you have any questions about our maresins analysis services, please contact us.

Reference:

  1. Tang S.; et al. Maresins: specialized proresolving lipid mediators and their potential role in inflammatory-related diseases. Mediators of inflammation. 2018.
* Our services can only be used for research purposes and Not for clinical use.

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