Very long chain fatty acid (VLCFA) is a fatty acid with a carbon number of more than 20. Ultra-long-chain fatty acids are precursors of lipid media, and are also constituents of cellular lipids such as sphingolipids and glycerophospholipids. Mutations in genes encoding extra-long-chain fatty acid metabolism enzymes can lead to a series of genetic diseases, such as ichthyosis, demyelination, myopathy, mental retardation, and macular degeneration. The identification of enzymes related to the synthesis and degradation of ultra-long-chain fatty acids can increase our understanding of the functions of ultra-long-chain fatty acids.
Ultra-long-chain fatty acids can be produced in all plant cells. Ultra-long-chain fatty acids are produced in specific cell types and are precursors or components of a large number of metabolites.
Creative Proteomics provides comprehensive very long chain fatty acids targeted lipidomics services from lipid extraction, lipid detection and data analysis for biomedical research institutions, biotechnology and pharmaceutical companies.
Fig 1. Scheme representation of very-long-chain fatty acid elongation (De Bigault, 2016)
Absolute quantification: Use external standard method to quantify, and use internal standard for correction, qualitative and quantitative is more accurate.
High sensitivity: we use liquid chromatography coupled with triple quadrupole mass spectrometers for very long chain fatty acids analysis service (Triple Quad™ 6500 LC-MS/MS System).
Fig 2. The workflow of very long chain fatty acids targeted lipidomics.
|Eicosanic acid (C22:0)||Forty-undecanoic acid (C24:0)||Hexadecanoic acid (C26:0)|
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