Lipidomics for Cancer Pathogenesis Research

Apart from biomarker discovery, lipidomics could help to reveal the pathogenesis related to cancer. Till now, numerous studies have shown that de novo FA synthesis was a critical regulator of cancer growth. Here are some studies.

• The sole carbon source and precursor for both FA and cholesterol biosynthesis in mammalian cells is acetyl-CoA. The study revealed that the activity of acetyl-CoA synthetase 2, an enzyme that converts acetate to acetyl-CoA, contributed to cancer cell growth under low-oxygen and lipid-depleted conditions by enhancing the ability of cancer cells to use acetate as an additional nutritional source. It was a potential molecular target for managing cancer growth.

Fig1. Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth (Schug.; et al, 2015)

• PLs also play an important role in cancer. Two of the most commonly activated pathways in human cancer are the PI3K‐Akt and the Ras pathways. A study investigated the function of individual PL in cell cycle regulation, showing that 20:4‐PC oscillates during the cell cycle and delays cell cycle progression by inhibiting Akt membrane binding.

With extensive experience and state-of-the-art technologies, Creative Proteomics offers cutting-edge mass spectrometry (MS)-based lipidomics services, including Untargeted Lipidomics Services, Targeted Lipidomcs Services, Metabolic flux Analysis Services for Cancer Pathogenesis Research.

• Featured services

• Our Platform

• Liquid chromatography hyphenated to high resolution /high accuracy mass spectrometry for untargeted lipidomics

Waters ACQUITY UPLC H Class Plus System + Waters Xevo G2-XS QTof Mass Spectrometry;
Waters ACQUITY UPLC H Class Plus System + Thermo Orbitrap Elite™ Hybrid Ion Trap-Orbitrap Mass Spectrometer;
Shimadzu Nexera X2 U-HPLC System + Thermo Orbitrap Elite™ Hybrid Ion Trap-Orbitrap Mass Spectrometer;
Waters ACQUITY UPLC H Class Plus System + Waters SYNAPT G2-Si HDMS+ Waters Xevo G2-XS QTof Mass Spectrometry.

• Shotgun throughput lipidomics analysis

TriVersa Nanomate nanoelectrospray ion source+ Orbitrap instruments.

Fig2. Creative Proteomics offers cutting-edge mass spectrometry (MS)-based lipidomics services (Creative Proteomics)

PLATFORM  

• Our Lipidomics Statistics

A detailed report will be provided at the end of the whole project, including the experiment procedure, MS/MS instrument parameter, raw data and data reports with figures, ready to be published.

How we work in 7 easy steps

If you have any questions about our lipidomics services for cancer pathogenesis research, please contact us. Our customer service representatives are available 24hr a day!

References:

1. Perrotti F., et al. Advances in lipidomics for cancer biomarkers discovery[J]. International journal of molecular sciences. 2016, 17(12): 1992.
2. Schug.; et al. Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer cell. 2015, 27.1: 57-71.